Purine and Pyrimidine Phosphoribosyltransferases: A Versatile Tool for Enzymatic Synthesis of Nucleoside-5'-monophosphates
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چکیده
منابع مشابه
The hydrolysis of purine and pyrimidine nucleoside triphosphates by myosin.
It is well established that myosin will catalyze the hydrolysis of inosine triphosphate’ (l-3) as well as ATP. Even catalysis of inorganic triphosphate hydrolysis has been observed (4, 5).2 It has been reported recently (7) that uridine triphosphate is rapidly hydrolyzed in the presence of crystalline myosin, and previously unpublished experiments3 showed that synthetically made UTP4 is rapidly...
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Evidence is presented that Salmonella typhimurium contains two guanine phosphoribosyltransferases.
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Molecular diversity plays a pivotal role in modern drug discovery against phenotypic or enzyme-based targets using high throughput screening technology. Under the auspices of the Pilot Scale Library Program of the NIH Roadmap Initiative, we produced and report herein a diverse library of 181 purine, pyrimidine, and 1,2,4-triazole-N-acetamide analogues which were prepared in a parallel high thro...
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Analogues of natural purines and pyrimidines have been synthesized and examined for biological activity, and a number of these have been found to inhibit the growth and metabolism of various tissues. Since certain of these compounds are more inhibitory to the growth of neoplastic than of normal cells, it is of importance that we understand the biochemical mechanisms by which they act. Much of t...
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1. Abstract 2. Introduction 3. Purine and pyrimidine metabolism during somatic embryogenesis 3.1. Maintenance of embryogenic tissue 3.1.1. Purine metabolism during maintenance of embryogenic tissue 3.1.2. Pyrimidine metabolism during maintenance of embryogenic tissue 3.2. Development of somatic embryos 3.2.1. Purine metabolism during development of somatic embryos 3.2.2. Pyrimidine metabolism d...
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ژورنال
عنوان ژورنال: Current Pharmaceutical Design
سال: 2018
ISSN: 1381-6128
DOI: 10.2174/1381612823666171017165707